Estimating the rates of crossover and gene conversion from individual genomes.

ABSTRACT: Recombination can occur either as a result of crossover or gene conversion events. Population genetic methods for inferring the rate of recombination from patterns of linkage disequilibrium generally assume a simple model of recombination that only involves crossover events and ignore gene conversion. However, distinguishing the 2 processes is not only necessary for a complete description of recombination, but also essential for understanding the evolutionary consequences of inversions and other genomic partitions in which crossover (but not gene conversion) is reduced. We present heRho, a simple composite likelihood scheme for coestimating the rate of crossover and gene conversion from individual diploid genomes. The method is based on analytic results for the distance-dependent probabili

SUBMITTER: Setter D 

PROVIDER: S-EPMC9434185 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature