Immunophenotyping of peripheral blood cells allows to discriminate MIS-C and Kawasaki disease.

ABSTRACT:

Background

The pathogenesis of the novel described multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) is still debated as it is not clear if they are the same or different nosological entities. However, for both the diseases a rapid and unequivocal diagnosis is mandatory to start the therapy before the onset of severe complications. In this study, we aimed to evaluate the white cell populations in MIS-C and KD as potential markers to discriminate between the two diseases.

Methods

We studied white cell populations by flow cytometry in 46 MIS-C and 28 KD patients in comparison to 70 age-matched healthy children.

Results

MIS-C patients had a significant lymphopenia that involved both B and T populations while KD patients showed a significant

SUBMITTER: Castaldo A 

PROVIDER: S-EPMC9440857 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature