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Assessing wastewater-based epidemiology for the prediction of SARS-CoV-2 incidence in Catalonia.


ABSTRACT: While wastewater-based epidemiology has proven a useful tool for epidemiological surveillance during the COVID-19 pandemic, few quantitative models comparing virus concentrations in wastewater samples and cumulative incidence have been established. In this work, a simple mathematical model relating virus concentration and cumulative incidence for full contagion waves was developed. The model was then used for short-term forecasting and compared to a local linear model. Both scenarios were tested using a dataset composed of samples from 32 wastewater treatment plants and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) incidence data covering the corresponding geographical areas during a 7-month period, including two contagion waves. A population-averaged dataset was also developed to model and predict the incidence over the full geography. Overall, the mathematical model based on wastewater data showed a good correlation with cumulative cases and allowed us to anticipate SARS-CoV-2 incidence in one week, which is of special relevance in situations where the epidemiological monitoring system cannot be fully implemented.

SUBMITTER: Joseph-Duran B 

PROVIDER: S-EPMC9443647 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Assessing wastewater-based epidemiology for the prediction of SARS-CoV-2 incidence in Catalonia.

Joseph-Duran Bernat B   Serra-Compte Albert A   Sàrrias Miquel M   Gonzalez Susana S   López Daniel D   Prats Clara C   Català Martí M   Alvarez-Lacalle Enric E   Alonso Sergio S   Arnaldos Marina M  

Scientific reports 20220905 1


While wastewater-based epidemiology has proven a useful tool for epidemiological surveillance during the COVID-19 pandemic, few quantitative models comparing virus concentrations in wastewater samples and cumulative incidence have been established. In this work, a simple mathematical model relating virus concentration and cumulative incidence for full contagion waves was developed. The model was then used for short-term forecasting and compared to a local linear model. Both scenarios were tested  ...[more]

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