Decreased vestibular efficacy contributes to abnormal balance in Parkinson's disease.

ABSTRACT:

Background and purpose

Abnormal balance is poorly responsive to dopaminergic therapy in Parkinson's disease (PD). Decreased vestibular efficacy may contribute to imbalance in PD. The purpose of this study was to investigate the relationship between vestibular measures of dynamic posturography and imbalance in PD while accounting for confounder variables.

Methods

106 patients with PD underwent dynamic posturography for the 6 conditions of the sensory integration test (SOT) using the Neurocom Equitest device. All SOT measures, nigrostriatal dopaminergic denervation ((+)-[¹¹C]DTBZ PET), brain acetylcholinesterase ([¹¹C]PMP PET), age, duration of disease, cognitive and parkinsonian motor scores, and ankle vibration sensitivity were used as regressors in a s

SUBMITTER: Bohnen NI 

PROVIDER: S-EPMC9444904 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature