Autophagy genes CCL2 and MYC are considered as potential biomarkers for pulmonary embolism.

ABSTRACT:

Objective

The pathogenesis of pulmonary embolism (PE) remains unclear. This study was designed to determine the differential genes associated with PE autophagy via the gene expression omnibus (GEO).

Methods

Microarray data sets GSE11851 and GSE13535 were downloaded from the GEO to determine the differentially expressed genes (DEGs) of PE, and the protein-protein interaction (PPI) and hub gene networks were constructed by string and Cytoscape software. Additionally, the two data sets were screened to find the autophagy-related genes with common differential expression. Then, autophagy-related hub genes (ARHGs) overlapping with autophagy-related genes and hub genes were identified. Next, the mRNA-miRNA network was constructed, and finally the expressions of hub genes were dete

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9452356 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature