Concomitant Cytotoxic Effector Differentiation of CD4⁺ and CD8⁺ T Cells in Response to EBV-Infected B Cells.

ABSTRACT: Most people infected by EBV acquire specific immunity, which then controls latent infection throughout their life. Immune surveillance of EBV-infected cells by cytotoxic CD4⁺ T cells has been recognized; however, the molecular mechanism of generating cytotoxic effector T cells of the CD4⁺ subset remains poorly understood. Here we compared phenotypic features and the transcriptome of EBV-specific effector-memory CD4⁺ T cells and CD8⁺ T cells in mice and found that both T cell types show cytotoxicity and, to our surprise, widely similar gene expression patterns relating to cytotoxicity. Similar to cytotoxic CD8⁺ T cells, EBV-specific cytotoxic CD4⁺ T cells from human peripheral blood expressed T-bet, Granzyme B, and Per

SUBMITTER: Tamura Y 

PROVIDER: S-EPMC9454722 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature