The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer.

ABSTRACT: The Wnt/β-catenin signalling pathway regulates multiple cellular processes during development and many diseases, including cell proliferation, migration, and differentiation. Despite their hydrophobic nature, Wnt proteins exert their function over long distances to induce paracrine signalling. Recent studies have identified several factors involved in Wnt secretion; however, our understanding of how Wnt ligands are transported between cells to interact with their cognate receptors is still debated. Here, we demonstrate that gastric cancer cells utilise cytonemes to transport Wnt3 intercellularly to promote proliferation and cell survival. Furthermore, we identify the membrane-bound scaffolding protein Flotillin-2 (Flot2), frequently overexpressed in gastric cancer, as a modulator of these

SUBMITTER: Routledge D 

PROVIDER: S-EPMC9457691 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature