Dataset Information

Fast acquisition of propagating waves in humans with low-field MRI: Toward accessible MR elastography.

ABSTRACT: Most commonly used at clinical magnetic fields (1.5 to 3 T), magnetic resonance elastography (MRE) captures mechanical wave propagation to reconstruct the mechanical properties of soft tissue with MRI. However, in terms of noninvasively assessing disease progression in a broad range of organs (e.g., liver, breast, skeletal muscle, and brain), its accessibility is limited and its robustness is challenged when magnetic susceptibility differences are encountered. Low-field MRE offers an opportunity to overcome these issues, and yet it has never been demonstrated in vivo in humans with magnetic fields <1.5 T mainly because of the long acquisition times required to achieve a sufficient signal-to-noise ratio. Here, we describe a method to accelerate 3D motion-sensitized MR scans at 0.1 T using only 10% k-space sampling combined with a high-performance detector and an efficient encoding acquisition strategy. Its application is demonstrated in vivo in the human forearm for a single motion-encoding direction in less than 1 min.

SUBMITTER: Yushchenko M

PROVIDER: S-EPMC9462689 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Fast acquisition of propagating waves in humans with low-field MRI: Toward accessible MR elastography.

Yushchenko Maksym M Sarracanie Mathieu M Salameh Najat N

Science advances 20220909 36

Most commonly used at clinical magnetic fields (1.5 to 3 T), magnetic resonance elastography (MRE) captures mechanical wave propagation to reconstruct the mechanical properties of soft tissue with MRI. However, in terms of noninvasively assessing disease progression in a broad range of organs (e.g., liver, breast, skeletal muscle, and brain), its accessibility is limited and its robustness is challenged when magnetic susceptibility differences are encountered. Low-field MRE offers an opportunity ...[more]

PMID: 36083901

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Project description:BackgroundMR elastography (MRE) at 60 Hz is widely used for staging liver fibrosis. MRE with lower frequencies may provide inflammation biomarkers.PurposeTo establish a practical simultaneous dual-frequency liver MRE protocol at both 30 Hz and 60 Hz during a single examination and validate the occurrence of second harmonic waves at 30 Hz.Study typeRetrospective.SubjectsOne hundred six patients (48 females, age: 50.0 ± 13.4 years) were divided as follows: Cohort One (15 patients with chronic liver disease [CLD] and 25 healthy volunteers) with simultaneous dual-frequency MRE. Cohort Two (66 patients with CLD) with second harmonic MRE.Field strength/sequence3-T, single- or dual-frequency MRE at 30 Hz and 60 Hz.AssessmentLiver stiffness (LS) in both cohorts was evaluated with manually placed volumetric ROIs by two independent analyzers. Image quality was assessed by three independent readers on a 4-point scale (0-3: none/failed, fair, moderate, excellent) based on the depth of wave propagation with 1/3 incremental penetration. The success rate was derived from the percentage of nonzero quality scores.Statistical testsMeasurement agreement, bias, and repeatability of LS were assessed using intraclass correlation coefficients (ICCs), Bland-Altman plots, and repeatability coefficient (RC). Mann-Whitney U tests were used to evaluate the differences in image quality between different methods. A P-value <0.05 was considered statistically significant.ResultsSuccess rate was 97.5% in Cohort One and 91% success rate for the second harmonic MRE in Cohort Two. The second harmonic and conventional MRE showed excellent agreement in LS (all ICCs >0.90). The quality scores for the second harmonic wave images were lower than those from the conventional MRE (Z = -4.523).Data conclusionCompared with conventional and second harmonic methods, simultaneous dual-frequency had better image quality, high success rate and the advantage of intrinsic co-registration, while the second harmonic method can be an alternative if custom waveform is not available.Evidence level3 TECHNICAL EFFICACY: Stage 1.

Project description:Multiple sclerosis (MS) is a chronic neuroinflammatory disease that involves both white and gray matter. Although gray matter damage is a major contributor to disability in MS patients, conventional clinical magnetic resonance imaging (MRI) fails to accurately detect gray matter pathology and establish a clear correlation with clinical symptoms. Using magnetic resonance elastography (MRE), we previously reported global brain softening in MS and experimental autoimmune encephalomyelitis (EAE). However, it needs to be established if changes of the spatiotemporal patterns of brain tissue mechanics constitute a marker of neuroinflammation. Here, we use advanced multifrequency MRE with tomoelastography postprocessing to investigate longitudinal and regional inflammation-induced tissue changes in EAE and in a small group of MS patients. Surprisingly, we found reversible softening in synchrony with the EAE disease course predominantly in the cortex of the mouse brain. This cortical softening was associated neither with a shift of tissue water compartments as quantified by T2-mapping and diffusion-weighted MRI, nor with leukocyte infiltration as seen by histopathology. Instead, cortical softening correlated with transient structural remodeling of perineuronal nets (PNNs), which involved abnormal chondroitin sulfate expression and microgliosis. These mechanisms also appear to be critical in humans with MS, where tomoelastography for the first time demonstrated marked cortical softening. Taken together, our study shows that neuroinflammation (i) critically affects the integrity of PNNs in cortical brain tissue, in a reversible process that correlates with disease disability in EAE, (ii) reduces the mechanical integrity of brain tissue rather than leading to water accumulation, and (iii) shows similar spatial patterns in humans and mice. These results raise the prospect of leveraging MRE and quantitative MRI for MS staging and monitoring treatment in affected patients.

Dataset Information

Fast acquisition of propagating waves in humans with low-field MRI: Toward accessible MR elastography.

Publications

Fast acquisition of propagating waves in humans with low-field MRI: Toward accessible MR elastography.

Similar Datasets

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