Efficacy and safety of extended duration to perioperative thromboprophylaxis with low molecular weight heparin on disease-free survival after surgical resection of colorectal cancer (PERIOP-01): multicentre, open label, randomised controlled trial.

ABSTRACT:

Objective

To determine the efficacy and safety of extended duration perioperative thromboprophylaxis by low molecular weight heparin when assessing disease-free survival in patients undergoing resection for colorectal cancer.

Design

Multicentre, open label, randomised controlled trial.

Settings

12 hospitals in Quebec and Ontario, Canada, between 25 October 2011 and 31 December 2020.

Participants

614 adults (age ≥18 years) were eligible with pathologically confirmed invasive adenocarcinoma of the colon or rectum, no evidence of metastatic disease, a haemoglobin concentration of ≥8 g/dL, and were scheduled to undergo surgical resection.

Interventions

Random assignment to extended duration thromboprophylaxis using daily subcutaneous tinzaparin at 4500 IU, b

SUBMITTER: Auer RC 

PROVIDER: S-EPMC9468899 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature