Lipid mediators are detectable in the nasal epithelium and differ by asthma status in female subjects.

ABSTRACT:

Background

Lipid mediators, bioactive products of polyunsaturated fatty acid metabolism, contribute to inflammation initiation and resolution in allergic diseases; however, their presence in lung-related biosamples has not been fully described.

Objective

We aimed to quantify lipid mediators in the nasal airway epithelium and characterize preliminary associations with asthma.

Methods

Using liquid chromatography-mass spectrometry, we conducted a pilot study to quantify 56 lipid mediators from nasal epithelial samples collected from 11 female participants of an outpatient asthma clinic and community controls (aged 30-55 years). We examined the presence of each compound using descriptive statistics to test whether lipid mediators could distinguish subjects with asthma (n 

SUBMITTER: Johnson RK 

PROVIDER: S-EPMC9475490 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature