Potential biomarkers for clinical outcomes of IVF cycles in women with/without PCOS: Searching with metabolomics.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a heterogeneous endocrinological and metabolic disorder which is the common cause of female infertility. The dysmetabolism displayed in it has not been completely ascertained. Metabonomics may shed light on understanding many small molecule endogenous metabolites and their associated metabolic pathways.

Objective

To analyze the different metabolites and related metabolic pathways in follicular fluid and embryo culture fluid of PCOS and non-PCOS groups. Finding markers predictable for clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET) treatment.

Population and sample

60 women who underwent IVF-ET were selected, including 30 with PCOS and 30 with the fallopian tubal issues only. We collected the fir

SUBMITTER: Guan SY 

PROVIDER: S-EPMC9478024 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature