Construction of CeRNA regulatory network based on WGCNA reveals diagnosis biomarkers for colorectal cancer.

ABSTRACT:

Background

Colorectal cancer is the third most common cause of death among cancers in the world. Although improvements in various treatments have greatly improved the survival time of colorectal cancer patients, since colorectal cancer is often at an advanced stage when diagnosed, the prognosis of patients is still very poor. Since the ceRNA regulatory network was proposed in 2011, it has greatly promoted the study of the molecular mechanism of colorectal cancer occurrence and development.

Objective

Exploring the new molecular mechanism of colorectal cancer occurrence and development and providing new targets for the diagnosis and treatment of colorectal cancer.

Method

We analyzed the RNA-seq data of CRC from TCGA, such as differential expression analysis, weighted ge

SUBMITTER: Xiang J 

PROVIDER: S-EPMC9482270 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature