Ontology highlight
ABSTRACT:
SUBMITTER: Cosovanu C
PROVIDER: S-EPMC9486084 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Cosovanu Catalina C Resch Philipp P Jordan Stefan S Lehmann Andrea A Ralser Markus M Farztdinov Vadim V Spranger Joachim J Mülleder Michael M Brachs Sebastian S Neumann Christian C
The Journal of experimental medicine 20220919 12
The primary function of the small intestine (SI) is to absorb nutrients to maintain whole-body energy homeostasis. Enterocytes are the major epithelial cell type facilitating nutrient sensing and uptake. However, the molecular regulators governing enterocytes have remained undefined. Here, we identify c-Maf as an enterocyte-specific transcription factor within the SI epithelium. c-Maf expression was determined by opposing Noggin/BMP signals and overlapped with the zonated enrichment of nutrient ...[more]