Non-Hodgkin's lymphoma masquerading as splenic abscess: A case report.

ABSTRACT:

Background

Non-Hodgkin's lymphoma (NHL) is a monoclonal proliferation of lymphoid cells from B lineage. Although NHLs are primarily hematological tumors of lymph nodes but rarely can involve extranodal sites such as the spleen.

Case report

A 29-year-old female patient presented with low-grade fever, cough, anemia, weight loss, tender left hypochondrium, and splenomegaly. A hypodense lesion in the spleen with central necrosis, having strong positivity for common leukocyte antigen (LCA), CD 20, and CD 10, led to a diffuse large B cell lymphoma diagnosis. The patient had an excellent clinical post-splenectomy response to combination chemotherapy and immunotherapy.

Conclusion

NHL can present with symptomatic extra-nodal involvement without enlarged lymph nodes.

SUBMITTER: Khan QA 

PROVIDER: S-EPMC9486706 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature