Treatment Outcome with High versus low-to-moderate Dosing of Corticosteroids in Early vis-a-vis Late-onset Hypoxic Cases of COVID-19: A Multicentric Retrospective Cohort Study.

ABSTRACT:

Background

Corticosteroid dosing in COVID-19 cases associated with early-onset and late-onset hypoxia have not been separately explored.

Methods

In this retrospective cohort study, we divided hypoxic COVID-19 cases into groups based on timing of initiation of corticosteroids relative to onset of symptoms; Group A (≤6th day), Group B (7th-9th day) and Group C (≥10th day), each group being sub-grouped into high and low-to-moderate dose corticosteroid recipients. Cox regression with propensity scoring was used to compare 28-day mortality between high and low-to-moderate dose recipients separately in Group A, Group B, Group C.

Results

Among 505 patients included, propensity score matched Cox regression showed greater risk of all-cause mortality among high dose recipients

SUBMITTER: Saha AK 

PROVIDER: S-EPMC9492392 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature