Protein Kinase CK2 Controls CD8⁺ T Cell Effector and Memory Function during Infection.

ABSTRACT: Protein kinase CK2 is a serine/threonine kinase composed of two catalytic subunits (CK2α and/or CK2α') and two regulatory subunits (CK2β). CK2 promotes cancer progression by activating the NF-κB, PI3K/AKT/mTOR, and JAK/STAT pathways, and also is critical for immune cell development and function. The potential involvement of CK2 in CD8⁺ T cell function has not been explored. We demonstrate that CK2 protein levels and kinase activity are enhanced upon mouse CD8⁺ T cell activation. CK2α deficiency results in impaired CD8⁺ T cell activation and proliferation upon TCR stimulation. Furthermore, CK2α is involved in CD8⁺ T cell metabolic reprogramming through regulating the AKT/mTOR pathway. Lastly, using a mouse Listeria monocytogenes infection m

SUBMITTER: Yang W 

PROVIDER: S-EPMC9492634 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature