A modified Delphi approach to develop a trial protocol for antibiotic de-escalation in patients with suspected sepsis

ABSTRACT:

Background:

Early administration of antibiotics in sepsis is associated with improved patient outcomes, but safe and generalizable approaches to de-escalate or discontinue antibiotics after suspected sepsis events are unknown.

Methods:

We used a modified Delphi approach to identify safety criteria for an opt-out protocol to guide de-escalation or discontinuation of antibiotic therapy after 72 hours in non-ICU patients with suspected sepsis. An expert panel with expertise in antimicrobial stewardship and hospital epidemiology rated 48 unique criteria across 3 electronic survey rating tools. Criteria were rated primarily based on their impact on patient safety and feasibility for extraction from electronic health record review. The 48 unique criteria were rated by anonymous

SUBMITTER: Yarrington M 

PROVIDER: S-EPMC9495406 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature