Dielectrophoresis-Based SERS Sensors for the Detection of Cancer Cells in Microfluidic Chips.

ABSTRACT: The detection of freely circulating cancer cells (CTCs) is one of the greatest challenges of modern medical diagnostics. For several years, there has been increased attention on the use of surface-enhanced Raman spectroscopy (SERS) for the detection of CTCs. SERS is a non-destructive, accurate and precise technique, and the use of special SERS platforms even enables the amplification of weak signals from biological objects. In the current study, we demonstrate the unique arrangement of the SERS technique combined with the deposition of CTCs cells on the surface of the SERS platform via a dielectrophoretic effect. The appropriate frequencies of an alternating electric field and a selected shape of the electric field can result in the efficient deposition of CTCs on the SERS platform. The ge

SUBMITTER: Szymborski TR 

PROVIDER: S-EPMC9496591 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature