Unknown

Dataset Information

0

Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones.

ABSTRACT: An efficient, three-component reaction of aldehydes and benzofuran-3-ones was developed. This process provides a new approach for the preparation of synthetically and biologically important spirobenzofuran-3-one derivatives with moderate-to-good yields under mild conditions. A switch of intramolecular to intermolecular domino Michael-aldol-lactonization leading to differential product formation was achieved by different NHCs catalysis.

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9503435 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones.

Wang Zhanyong Z   Yang Ting T   Liu Dongfang D   Chen Rongxiang R   Wang Nan N   Liu Hong H   Li Jiarong J   Wang Kaikai K   Liu Hongxin H  

Molecules (Basel, Switzerland) 20220913 18

An efficient, three-component reaction of aldehydes and benzofuran-3-ones was developed. This process provides a new approach for the preparation of synthetically and biologically important spirobenzofuran-3-one derivatives with moderate-to-good yields under mild conditions. A switch of intramolecular to intermolecular domino Michael-aldol-lactonization leading to differential product formation was achieved by different NHCs catalysis. ...[more]

Similar Datasets

Unknown Double diastereoselective, nucleophile-catalyzed aldol lactonizations (NCAL) leading to beta-lactone fused carbocycles and extensions to beta-lactone fused tetrahydrofurans.
| S-EPMC2933739 | biostudies-literature
Unknown Stereocontrolled access to δ-lactone-fused-γ-lactams bearing angular benzylic quaternary stereocenters.
| S-EPMC9194931 | biostudies-literature
Unknown Ru-NHC-Catalyzed Asymmetric, Complete Hydrogenation of Indoles and Benzofurans: One Catalyst with Dual Function.
| S-EPMC10375535 | biostudies-literature
Unknown NHC-Cu-catalyzed protoboration of monosubstituted allenes. Ligand-controlled site selectivity, application to synthesis and mechanism.
| S-EPMC3625862 | biostudies-literature
Unknown Cyclic ketimines as superior electrophiles for NHC-catalyzed homoenolate additions with broad scope and low catalyst loadings.
| S-EPMC2631935 | biostudies-literature
Unknown Regioselective Ru(ii)-catalyzed C–H alkenylation and annulation of indoles: a direct approach to fused lactone scaffolds
| S-EPMC12378404 | biostudies-literature
Unknown Chemoselective Synthesis of δ-Amino Alcohols from Chiral 1,4-Diols Catalyzed by an NHC-Ir(III) Complex.
| S-EPMC12814538 | biostudies-literature
Unknown Ruthenaelectro-catalyzed C-H phosphorylation: <i>ortho</i> to <i>para</i> position-selectivity switch.
| S-EPMC11619359 | biostudies-literature
Unknown Hydroamination of alkynes catalyzed by NHC-Gold(I) complexes: the non-monotonic effect of substituted arylamines on the catalyst activity.
| S-EPMC10731675 | biostudies-literature
Unknown A fused [3.3.0]-neoglycoside lactone derived from glucuronic acid.
| S-EPMC3769141 | biostudies-literature