Comparative Role of ¹⁸F-DOPA PET/CT and ¹³¹I-MIBG Scintigraphy in Neuroblastoma and Application of Curie and SIOPEN Scoring Systems in ¹⁸F-DOPA PET/CT.

ABSTRACT:

Purpose

Neuroblastoma (NB) is childhood's most common extracranial solid malignancy. We have compared two imaging modalities, ¹³¹I-MIBG and ¹⁸F-DOPA PET/CT, to evaluate NB. Also, feasibility of the application of standardised scoring systems, SIOPEN and Curie scoring systems, in ¹⁸F-DOPA PET/CT was explored.

Methods

Patients with histopathology-proven NB underwent ¹³¹I-MIBG (planar and SPECT/CT) and ¹⁸F-DOPA PET/CT scans, as per standard imaging protocols. Duration between scans ranged from 1 to 30 days (median = 8 days). Number of lesions in Curie and SIOPEN scoring systems applied on both modalities was compared.

Results

Forty-six patients were included (M:F = 29:17) with a median age of 36 months. Both ¹³¹

SUBMITTER: Hemrom A 

PROVIDER: S-EPMC9508302 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature