Selective corticocortical connectivity suppression during propofol-induced anesthesia in healthy volunteers.

ABSTRACT: We comprehensively studied directional feedback and feedforward connectivity to explore potential connectivity changes that underlie propofol-induced deep sedation. We further investigated the corticocortical connectivity patterns within and between hemispheres. Sixty-channel electroencephalographic data were collected from 19 healthy volunteers in a resting wakefulness state and propofol-induced deep unconsciousness state defined by a bispectral index value of 40. A source analysis was employed to locate cortical activity. The Desikan-Killiany atlas was used to partition cortices, and directional functional connectivity was assessed by normalized symbolic transfer entropy between higher-order (prefrontal and frontal) and lower-order (auditory, sensorimotor and visual) cortices and between

SUBMITTER: Wang H 

PROVIDER: S-EPMC9508318 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature