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New insights into vitamin K biology with relevance to cancer.

ABSTRACT: Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential for post-translational γ-carboxylation of a small number of proteins, including clotting factors. These modified proteins have now been implicated in diverse physiological and pathological processes including cancer. Vitamin K intake has been inversely associated with cancer incidence and mortality in observational studies. Newly discovered functions of vitamin K in cancer cells include activation of the steroid and xenobiotic receptor (SXR) and regulation of oxidative stress, apoptosis, and autophagy. We provide an update of vitamin K biology, non-canonical mechanisms of vitamin K actions, the potential functions of vitamin K-dependent proteins in cancer, and observational trials on vitamin K intake and cancer.

SUBMITTER: Welsh J

PROVIDER: S-EPMC9509427 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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New insights into vitamin K biology with relevance to cancer.

Welsh JoEllen J Bak Min Ji MJ Narvaez Carmen J CJ

Trends in molecular medicine 20220823 10

Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential for post-translational γ-carboxylation of a small number of proteins, including clotting factors. These modified proteins have now been implicated in diverse physiological and pathological processes including cancer. Vitamin K intake has been inversely associated with cancer incidence and mortality in observational studies. Newly discovered functions of vitamin K in cancer cells include activation of the steroid and xe ...[more]

PMID: 36028390

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New insights into vitamin K biology with relevance to cancer.

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New insights into vitamin K biology with relevance to cancer.

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