Increased tissue water in patients with severe sepsis affects tissue oxygenation measured by near-infrared spectroscopy: a prospective, observational case-control study.

ABSTRACT:

Background

Tissue oedema affects tissue perfusion and interferes with the monitoring of tissue oxygenation in patients with severe sepsis. However, the underlying mechanisms remain unclear. We used a wireless near-infrared spectroscopy (NIRS) device that transmits tri-wavelength light to quantify tissue haemoglobin (Hb) and water (H₂O) content. We estimated tissue H₂O in severe sepsis patients and healthy controls, compared their difference, and investigated the correlation of tissue H₂O with systemic haemodynamics and its impact on tissue oxygenation.

Methods

Seventy-seven adult patients with new-onset severe sepsis admitted to the intensive care unit within 72 h and 30 healthy volunteers (controls) were enrolled. The NIRS device was placed

SUBMITTER: Lin CK 

PROVIDER: S-EPMC9511429 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature