Gene-environment interactions explain a substantial portion of variability of common neuropsychiatric disorders.

ABSTRACT: In complex diseases, the phenotypic variability can be explained by genetic variation (G), environmental stimuli (E), and interaction of genetic and environmental factors (G-by-E effects), among which the contribution G-by-E remains largely unknown. In this study, we focus on ten major neuropsychiatric disorders using data for 138,383 United States families with 404,475 unique individuals. We show that, while gene-environment interactions account for only a small portion of the total phenotypic variance for a subset of disorders (depression, adjustment disorder, substance abuse), they explain a rather large portion of the phenotypic variation of the remaining disorders: over 20% for migraine and close to or over 30% for anxiety/phobic disorder, attention-deficit/hyperactivity disorder, rec

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9512674 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature