Aggressive pituitary tumours and carcinomas, characteristics and management of 171 patients.

ABSTRACT:

Objective

To describe clinical and pathological characteristics and treatment outcomes in a large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC).

Design

Electronic survey August 2020-May 2021.

Results

96% of 171 (121 APT, 50 PC), initially presented as macro/giant tumours, 6 were microadenomas (5 corticotroph). Ninety-seven tumours, initially considered clinically benign, demonstrated aggressive behaviour after 5.5 years (IQR: 2.8-12). Of the patients, 63% were men. Adrenocorticotrophic hormone (ACTH)-secreting tumours constituted 30% of the APT/PC, and the gonadotroph subtypes were under-represented. Five out of 13 silent corticotroph tumours and 2/6 silent somatotroph tumours became secreting. Metastases were observed after median 6.3 years (

SUBMITTER: Burman P 

PROVIDER: S-EPMC9513638 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature