Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos.

ABSTRACT: Metabolism feeds into the regulation of epigenetics via metabolic enzymes and metabolites. However, metabolic features, and their impact on epigenetic remodeling during mammalian pre-implantation development, remain poorly understood. In this study, we established the metabolic landscape of mouse pre-implantation embryos from zygote to blastocyst, and quantified some absolute carbohydrate metabolites. We integrated these data with transcriptomic and proteomic data, and discovered the metabolic characteristics of the development process, including the activation of methionine cycle from 8-cell embryo to blastocyst, high glutaminolysis metabolism at blastocyst stage, enhanced TCA cycle activity from the 8-cell embryo stage, and active glycolysis in the blastocyst. We further demonstrated tha

SUBMITTER: Li J 

PROVIDER: S-EPMC9515074 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature