Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology.

ABSTRACT: It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shared alterations of cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression disorder, obsessive-compulsive disorder, bipolar disorder, and schizophrenia). Our framework cross-referenced shared morphological anomalies with respect to cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patients

SUBMITTER: Park BY 

PROVIDER: S-EPMC9515219 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature