Immune response after COVID-19 vaccination among patients with chronic kidney disease and kidney transplant.

ABSTRACT:

Background

Vaccination of patients with chronic kidney disease (CKD) and kidney transplants (KTs) may achieve a less robust immune response. Understanding such immune responses is crucial for guiding current and future vaccine dosing strategies.

Methods

This prospective, observational study estimated the immunogenicity of humoral and cellular responses of two SARS-CoV-2 vaccines in different patient groups with CKD compared with controls. Secondary outcomes included adverse events after vaccination and the incidence of COVID-19 breakthrough infection, including illness severity.

Results

In total, 212 patients received ChAdOx1 nCoV-19 (89.62 %) or inactivated vaccines (10.38 %).The antibody response against the S protein was analyzed at T0 (before the first injection),

SUBMITTER: Trakarnvanich T 

PROVIDER: S-EPMC9515331 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature