Maternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes.

ABSTRACT: Gestational arsenic exposure adversely impacts child health. Folate-mediated 1-carbon metabolism facilitates urinary excretion of arsenic and may prevent arsenic-related adverse health outcomes. We investigated the potential for maternal folate status to modify associations between gestational arsenic exposure and child health. We used data from 364 mother-child pairs in the MIREC study, a prospective pan-Canadian cohort. During pregnancy, we measured first trimester urinary arsenic concentrations, plasma folate biomarkers, and folic acid supplementation intake. At age 3 years, we evaluated twelve neurodevelopmental and anthropometric features. Using latent profile analysis and multinomial regression, we developed phenotypic profiles of child health, estimated covariate-adjusted associatio

SUBMITTER: Patti MA 

PROVIDER: S-EPMC9517145 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature