Comprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk.

ABSTRACT:

Background

Ductal carcinoma in situ (DCIS) is treated to prevent subsequent ipsilateral invasive breast cancer (iIBC). However, many DCIS lesions will never become invasive. To prevent overtreatment, we need to distinguish harmless from potentially hazardous DCIS. We investigated whether the immune microenvironment (IME) in DCIS correlates with transition to iIBC.

Methods

Patients were derived from a Dutch population-based cohort of 10,090 women with pure DCIS with a median follow-up time of 12 years. Density, composition and proximity to the closest DCIS cell of CD20⁺ B-cells, CD3⁺CD8⁺ T-cells, CD3⁺CD8^- T-cells, CD3⁺FOXP3⁺ regulatory T-cells, CD68⁺ cells, and CD8⁺Ki67⁺

SUBMITTER: Almekinders MM 

PROVIDER: S-EPMC9519539 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature