A water-soluble membrane transporter for biologically relevant cations.

ABSTRACT: Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.

SUBMITTER: Yang K 

PROVIDER: S-EPMC9520675 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature