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A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior.

ABSTRACT:

Background

An essential determinant of a neuron's functionality is its neurotransmitter phenotype. We previously identified a defined subpopulation of cholinergic neurons required for social orienting behavior in zebrafish.

Results

We transcriptionally profiled these neurons and discovered that they are capable of synthesizing both acetylcholine and GABA. We also established a constellation of transcription factors and neurotransmitter markers that can be used as a "transcriptomic fingerprint" to recognize a homologous neuronal population in another vertebrate.

Conclusion

Our results suggest that this transcriptomic fingerprint and the cholinergic-GABAergic neuronal subtype that it defines are evolutionarily conserved.

SUBMITTER: Ncube D

PROVIDER: S-EPMC9523972 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior.

Ncube Denver D Tallafuss Alexandra A Serafin Jen J Bruckner Joseph J Farnsworth Dylan R DR Miller Adam C AC Eisen Judith S JS Washbourne Philip P

BMC genomics 20220929 1

<h4>Background</h4>An essential determinant of a neuron's functionality is its neurotransmitter phenotype. We previously identified a defined subpopulation of cholinergic neurons required for social orienting behavior in zebrafish.<h4>Results</h4>We transcriptionally profiled these neurons and discovered that they are capable of synthesizing both acetylcholine and GABA. We also established a constellation of transcription factors and neurotransmitter markers that can be used as a "transcriptomic ...[more]

PMID: 36175871

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