Talaromyces marneffei Infections in 8 Chinese Children with Inborn Errors of Immunity.

ABSTRACT:

Purpose

Talaromyces marneffei (TM) is an opportunistic fungus leading to multi-organ damages and poor prognosis in immunocompromised individuals. TM infections in children are rare and our knowledge to TM infection is insufficient. To investigate the clinical characteristics of TM-infected children and to explore the underlying mechanisms for host against TM, we analysed TM-infected patients diagnosed in our hospital.

Methods

Eight patients with TM infections have been identified in Shenzhen Children's Hospital during 2017-2021. Clinical data were collected from medical records. Immunological features were evaluated by flow cytometry. Literatures were also reviewed to summarize the reported inborn errors of immunity (IEIs) with TM infections.

Results

All 8 children we

SUBMITTER: Wang L 

PROVIDER: S-EPMC9524311 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature