Outcomes Associated With Timing of Neurologic Dysfunction Onset Relative to Pediatric Sepsis Recognition.

ABSTRACT:

Objectives

To compare outcomes associated with timing-early versus late-of any neurologic dysfunction during pediatric sepsis.

Design

Secondary analysis of a cross-sectional point prevalence study.

Setting

A total of 128 PICUs in 26 countries.

Patients

Less than 18 years with severe sepsis on 5 separate days (2013-2014).

Interventions

None.

Measurements and main results

Patients were categorized as having either no neurologic dysfunction or neurologic dysfunction (i.e., present at or after sepsis recognition), which was defined as Glasgow Coma Scale score less than 5 and/or fixed dilated pupils. Our primary outcome was death or new moderate disability (i.e., Pediatric Overall [or Cerebral] Performance Category score ≥3 and change ≥1 from baseline)

SUBMITTER: Alcamo AM 

PROVIDER: S-EPMC9524404 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature