Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is known to be associated with cognitive decline and brain structural changes. This study systematically reviews and estimates human brain volumetric differences and atrophy associated with T2DM.

Methods

PubMed, PsycInfo and Cochrane Library were searched for brain imaging studies reporting on brain volume differences between individuals with T2DM and healthy controls. Data were examined using meta-analysis, and association between age, sex, diabetes characteristics and brain volumes were tested using meta-regression.

Results

A total of 14,605 entries were identified; after title, abstract and full-text screening applying inclusion and exclusion criteria, 64 studies were included and 42 studies with compatible data contribute

SUBMITTER: Zhang T 

PROVIDER: S-EPMC9532183 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature