Selective Cell Size MRI Differentiates Brain Tumors from Radiation Necrosis.

ABSTRACT: Brain metastasis is a common characteristic of late-stage lung cancers. High doses of targeted radiotherapy can control tumor growth in the brain but can also result in radiotherapy-induced necrosis. Current methods are limited for distinguishing whether new parenchymal lesions following radiotherapy are recurrent tumors or radiotherapy-induced necrosis, but the clinical management of these two classes of lesions differs significantly. Here, we developed, validated, and evaluated a new MRI technique termed selective size imaging using filters via diffusion times (SSIFT) to differentiate brain tumors from radiotherapy necrosis in the brain. This approach generates a signal filter that leverages diffusion time dependence to establish a cell size-weighted map. Computer simulations in silico,

SUBMITTER: Devan SP 

PROVIDER: S-EPMC9532360 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature