Acute tryptophan depletion balances altered resting-state functional connectivity of the salience network in female patients recovered from anorexia nervosa.

ABSTRACT:

Background

It has been suggested that individuals predisposed to or recovered from anorexia nervosa experience a hyperserotonergic state associated with anxiety that might be mitigated by restricted food intake, because diminished levels of the tryptophan precursor lower the central availability of serotonin (5-HT). At the neural level, the salience network is a system of functionally connected brain regions; it has been closely associated with 5-HT functioning and mental disorders (including anorexia nervosa). The aim of the present study was to investigate the effect on the salience network of a temporary dietary manipulation of 5-HT synthesis in patients with anorexia nervosa.

Methods

In this double-blind crossover study, we obtained data on resting-state functional conne

SUBMITTER: Boehm I 

PROVIDER: S-EPMC9533767 | biostudies-literature | 2022 Sep-Oct

REPOSITORIES: biostudies-literature