Global changes in diffusion tensor imaging during acute ischemic stroke and post-stroke cognitive performance.

ABSTRACT: Post-stroke cognitive impairment is related to the effects of the acute stroke and pre-stroke brain health. We tested whether diffusion tensor imaging (DTI) can detect acute, global effects of stroke and predict post-stroke cognitive performance. Patients with stroke or TIA enrolled in a prospective cohort study were included if they had 1) at least one DTI acquisition at acute presentation, 24 hours, 5 days, or 30 days, and 2) follow-up testing with the telephone Montreal Cognitive Assessment (T-MoCA) at 30 and/or 90 days. A whole brain, white-matter skeleton excluding the infarct was used to derive mean global DTI measures for mean diffusivity (MD), fractional anisotropy (FA), free water (FW), FW-corrected MD (MD_tissue), and FW-corrected FA (FA_tissue). In 74 patient

SUBMITTER: Kern KC 

PROVIDER: S-EPMC9536124 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature