Evolution of SIVmac239 following serial passaging in humanized mice.

ABSTRACT: Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross-species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4⁺ T cell decline and increases in plasma viral loads.

SUBMITTER: Curlin JZ 

PROVIDER: S-EPMC9536747 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature