Evolution of SIVmac239 following serial passaging in humanized mice.
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ABSTRACT:
SUBMITTER: Curlin JZ
PROVIDER: S-EPMC9536747 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Publications
Evolution of SIVmac239 following serial passaging in humanized mice.
Curlin James Z JZ Schmitt Kimberly K Remling-Mulder Leila L Morrison Jared J Baczenas John J JJ Tibbits Corina Valencia CV Goff Kelly K O'Connor Shelby S Stenglein Mark M Marx Preston P Akkina Ramesh R
Journal of medical primatology 20220828 5
Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross-species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4<sup>+</sup> T cell decline and increases in plasma viral loads. ...[more]
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