Functional Brain Dysconnectivity in Parkinson's Disease: A 5-Year Longitudinal Study.

ABSTRACT:

Background

Tracking longitudinal functional brain dysconnectivity in Parkinson's disease (PD) is a key element to decoding the underlying physiopathology and understanding PD progression.

Objectives

The objectives of this follow-up study were to explore, for the first time, the longitudinal changes in the functional brain networks of PD patients over 5 years and to associate them with their cognitive performance and the lateralization of motor symptoms.

Methods

We used a 5-year longitudinal cohort of PD patients (n = 35) who completed motor and non-motor assessments and sequent resting state (RS) high-density electroencephalography (HD-EEG) recordings at three timepoints: baseline (BL), 3 years follow-up (3YFU) and 5 years follow-up (5YFU). We assessed disruptions in

SUBMITTER: Yassine S 

PROVIDER: S-EPMC9543227 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature