Expression and function of resolvin RvD1_{n-3 DPA} receptors in oral epithelial cells.

ABSTRACT: Chronic inflammatory responses can inflict permanent damage to host tissues. Specialized pro-resolving mediators downregulate inflammation but also can have other functions. The aim of this study was to examine whether oral epithelial cells express the receptors FPR2/ALX and DRV1/GPR32, which bind RvD1_{n-3 DPA} , a recently described pro-resolving mediator derived from omega-3 docosapentaenoic acid (DPA), and whether RvD1_{n-3 DPA} exposure induced significant responses in these cells. Gingival biopsies were stained using antibodies to FPR2/ALX and DRV1/GPR32. Expression of FPR2/ALX and DRV1/GPR32 was examined in primary oral epithelial cells by qRT-PCR, flow cytometry, and immunofluorescence. The effect of RvD1_{n-3 DPA} on intracellular calcium mobilization and t

SUBMITTER: Balta MG 

PROVIDER: S-EPMC9544308 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature