Comprehensive phenotyping of human peripheral blood B lymphocytes in healthy conditions.

ABSTRACT: The B cell compartment provides innate and adaptive immune defenses against pathogens. Different B cell subsets, reflecting the maturation stages of B cells, have noninterchangeable functions and roles in innate and adaptive immune responses. In this review, we provide an overview of the B cell subsets present in peripheral blood of healthy individuals. A specific gating strategy is also described to clearly and univocally identify B cell subsets based on the their phenotypic traits by flow cytometric analysis.

SUBMITTER: Carsetti R 

PROVIDER: S-EPMC9546334 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature