Individual differences in cocaine-induced conditioned place preference in male rats: Behavioral and transcriptomic evidence.

ABSTRACT:

Background

Substance use disorder emerges in a small proportion of drug users and has the characteristics of a chronic relapsing pathology.

Aims

Our study aimed to demonstrate and characterize the variability in the expression of the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm.

Methods

A cocaine-CPP paradigm in male Sprague-Dawley rats with an extinction period of 12 days and reinstatement was conducted. A statistical model was developed to distinguish rats expressing or not a cocaine-induced place preference.

Results

Two groups of rats were identified: rats that did express rewarding effects (CPP expression (CPPE), score >102 s) and rats that did not (no CPP expression (nCPPE), score between -85 and 59 s). These two groups d

SUBMITTER: Atehortua Martinez LA 

PROVIDER: S-EPMC9548661 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature