Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case-control and meta-analysis study.

ABSTRACT:

Objective

Several studies have shown that miR-146a rs2910164 (C > G) is associated with type 2 diabetes mellitus (T2DM) susceptibility, but the results are still controversial. This study is divided into two parts, and one is to explore the relationship between miR-146a rs2910164 polymorphism and the genetic susceptibility of T2DM in Chinese Han population. Second, a meta-analysis on the basis of a larger sample size was used to determine whether this is a susceptibility gene for T2DM.

Methods

A case-control study including 574 T2DM patients and 596 controls was used to evaluate the association of miR-146a rs2910164 polymorphism with the risk of T2DM in Chinese Han People. Then, we systematically searched studies investigating the correlation between miR-146a rs2910164 polym

SUBMITTER: Chang WW 

PROVIDER: S-EPMC9551998 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature