Screening and verification of prognostic lncRNA markers related to immune infiltration in the metastasis of osteosarcoma.

ABSTRACT:

Background

We sought to screen and verify the long non-coding ribonucleic acids (lncRNAs) related to immune infiltration in metastatic osteosarcoma (OS).

Methods

We downloaded the RNA-sequencing expression data from The Cancer Genome Atlas (TCGA) database as the training data set. We downloaded the GSE39055 data set from the National Center for Biotechnology Information, Gene Expression Omnibus as the validation data set. The least absolute shrinkage and selection operator (LASSO) regression algorithm was used to screen the optimized lncRNA combinations. Kaplan-Meier curves were used to evaluate the associations between the lncRNAs and actual prognosis. The independent survival prognosis clinical factors were obtained by univariate and multivariate Cox analyses. A nomogram w

SUBMITTER: He C 

PROVIDER: S-EPMC9552095 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature