CXCL14 exacerbates seizures by inhibiting GABA metabolism in epileptic mice.

ABSTRACT:

Objective

Epilepsy is a common central nervous system disorder with pathological mechanisms including inflammation, ion channel impairment, and neurotransmitter imbalance. Despite the rapid development of current anti-epileptic drugs, epilepsy is not well controlled, so there is still a need for research on the mechanisms and new drug targets for epilepsy. CXCL14 is a member of the CXC family of chemokines, and its receptor is currently unknown. Chemokines are the third major communication mediators in the central nervous system and play a role in many diseases. Therefore, we explore the expression of CXCL14 in epilepsy and its possible mechanisms.

Materials and methods

We chose the kainic acid (KA) mouse model as the epilepsy model, and studied the expression of CXCL14 in t

SUBMITTER: Chen M 

PROVIDER: S-EPMC9556486 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature