A Network of Serum Proteins Predict the Need for Systemic Immunomodulatory Therapy at Diagnosis in Noninfectious Uveitis.

ABSTRACT:

Purpose

Early identification of patients with noninfectious uveitis requiring steroid-sparing immunomodulatory therapy (IMT) is currently lacking in objective molecular biomarkers. We evaluated the proteomic signature of patients at the onset of disease and associated proteomic clusters with the need for IMT during the course of the disease.

Design

Multicenter cohort study.

Participants

Two hundred thirty treatment-free patients with active noninfectious uveitis.

Methods

We used aptamer-based proteomics (n = 1305 proteins) and a bioinformatic pipeline as a molecular stratification tool to define the serum protein network of a Dutch discovery cohort (n = 78) of patients and healthy control participants and independently validated our results in another Dutch coh

SUBMITTER: Kuiper JJW 

PROVIDER: S-EPMC9559086 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature