Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study.

ABSTRACT:

Purpose

To elucidate the differences in ocular biometric parameters by generation and gender and to identify axial length (AL)-associated genetic variants in Japanese individuals, we analyzed Tohoku Medical Megabank Organization (ToMMo) Eye Study data.

Design

We designed the ToMMo Eye Study, examined AL variations, and conducted genome-wide association studies (GWASs).

Participants

In total, 33 483 participants aged > 18 years who were recruited into the community-based cohort (CommCohort) and the birth and three-generation cohort (BirThree Cohort) of the ToMMo Eye Study were examined.

Methods

Each participant was screened with an interview, ophthalmic examinations, and a microarray analysis. The GWASs were performed in 22 379 participants in the CommCohort (di

SUBMITTER: Fuse N 

PROVIDER: S-EPMC9559092 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature