Association of Inner Retinal Thickness with Prevalent Dementia and Brain Atrophy in a General Older Population: The Hisayama Study.

ABSTRACT:

Purpose

To assess the association of inner retinal thickness with prevalent dementia and regional brain atrophy in a general older population of Japanese.

Design

Population-based, cross-sectional study.

Participants

A total of 1078 residents aged 65 years or older who participated in an eye examination, a comprehensive survey of dementia, and brain magnetic resonance imaging scanning in 2017.

Methods

The thicknesses of the inner retinal layers, namely, the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL)-were measured by swept-source OCT (SS-OCT). The association of these retinal thicknesses with the risk of the presence of dementia was estimated using restricted cubic splines and logistic regression models. Regional brain volum

SUBMITTER: Ueda E 

PROVIDER: S-EPMC9559916 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature