Insomnia and sleep duration on COVID-19 susceptibility and hospitalization: A Mendelian randomization study.

ABSTRACT:

Background

Sleep disturbance including insomnia and sleep duration is associated with an increased risk of infectious. With the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is important to explore potential causal associations of sleep disturbance on COVID-19 susceptibility and hospitalization.

Method

Insomnia and sleep duration were selected as exposure. Outcomes included susceptibility and hospitalization for COVID-19. Two sample mendelian randomization design was used to assess causality between sleep and COVID-19. Inverse variance weighted method was used as main analysis method to combine the ratio estimates for each instrumental variable to obtain the causal effect. Cochran's Q statistic was used to test for global heterogeneity. MR-Egger and weighting medi

SUBMITTER: Peng L 

PROVIDER: S-EPMC9561394 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature